TC Mps1 12
Cat. No. 4750
Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethy
Biological ActivityPotent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kusakabe et al (2012) Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med.Chem.Lett. 3 560. PMID: 24900510.
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Keywords: TC Mps1 12, supplier, TCMps112, TC, Mps1, 12, potent, selective, monopolar, spindle, 1, mps1, antitumor, orally, active, Tocris Bioscience, Monopolar Spindle 1 Kinase Inhibitor products
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