TC Mps1 12

Cat. No. 4750

TC Mps1 12  [1206170-62-8]

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Chemical Name: 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide

Biological Activity

Potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM). Selective for Mps1 over a panel of 95 kinases including JNK. Inhibits A549 lung carcinoma cell proliferation and attenuates A549 cell xenograft growth in mice. Orally active.

Technical Data

M.Wt:
324.38
Formula:
C17H20N6O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1206170-62-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kusakabe et al (2012) Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med.Chem.Lett. 3 560. PMID: 24900510.

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Keywords: TC Mps1 12, supplier, TCMps112, TC, Mps1, 12, potent, selective, monopolar, spindle, 1, mps1, antitumor, orally, active, Tocris Bioscience, Monopolar Spindle 1 Kinase Inhibitor products

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