Cat. No. 4749
Biological ActivityCalcium sensing receptor (CaSR) agonist. Activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Enhances osteogenic differentiation of mesenchymal stem cells.
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Certificate of Analysis / Safety Data Sheet
Thomsen et al (2012) Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells. J.Pharmacol.Exp.Ther. 343 638. PMID: 22942242.
Yang et al (2011) Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling. Stem Cells 29 981. PMID: 21563277.
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Keywords: Strontium chloride, supplier, calcium, sensing, receptor, CaSR, agonists, ERK1/2, calcitonin, secretion, osteogenic, differentiation, stem, cells, Tocris Bioscience, Calcium-Sensing Receptor Agonist products
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