TC-G 1006

Cat. No. 4747

TC-G 1006 C21H16F3N3O3 [1324003-64-6]

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Chemical Name: 4-Methoxy-N-[[[2-trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 35 nM), displays >100-fold selectivity against receptor subtypes S1P2-5. Induces a dose-dependent reduction in circulating blood lymphocyte counts in rodent models. Orally bioavailable.

Technical Data

M.Wt:
415.37
Formula:
C21H16F3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1324003-64-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Pennington et al (2011) 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med.Chem.Lett. 2 752. PMID: 24900263.

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Keywords: TC-G 1006, supplier, TC-G1006, Sphingosine-1-phosphate, receptor, 1, agonists, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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