Cat. No. 4746

ML SA1 C22H22N2O3 [332382-54-4]

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Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Biological Activity

Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Technical Data

Soluble to 20 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731. PMID: 22415822.

Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111. PMID: 22808310.

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Keywords: ML SA1, supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, Tocris Bioscience, TRPML Activator products

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