ML SA1

Cat. No. 4746

ML SA1 C22H22N2O3 [332382-54-4]

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Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Biological Activity

Activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Technical Data

M.Wt:
362.42
Formula:
C22H22N2O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
332382-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shen et al (2012) Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 3 731. PMID: 22415822.

Weiss et al (2012) Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 5 111. PMID: 22808310.

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Keywords: ML SA1, supplier, MLSA1, trpml, transient, receptor, potential, channels, mucolipin, TRPML1, TRPML2, TRPML3, lysosomal, lysosome, storage, diseases, Tocris Bioscience, TRPML Activator products

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