Cat. No. 4744

P11 His-Ser-Asp-Val-His-Lys-NH2

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Biological Activity

Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Technical Data


(Modifications: Lys-6 = C-terminal amide)

Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10 M110. PMID: 21558493.

Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10 72. PMID: 19882657.

Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9 687. PMID: 15634795.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: P11, supplier, integrin, alpha, v, beta, 3, avb3, antagonists, vitronectin, potent, antiangiogenics, angiogenesis, Tocris Bioscience, Integrin Inhibitor products

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