Cat. No. 4742
Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']
Biological ActivityOxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631. PMID: 22634634.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Gue 1654 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Gue 1654, supplier, Gue1654, OXE-R, modulators, inhibitors, inhibits, selective, beta, gamma, β, γ, signalling, signaling, heterotrimeric, G-proteins, oxeiocosanoid, receptors, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity caveolin-1 ligandSAG 21k
Hedgehog signaling activator; brain penetrant and orally bioavailable
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.