Gue 1654

Cat. No. 4742

Gue 1654 C23H17N3OS3 [397290-30-1]

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Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide

Biological Activity

Oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.

Technical Data

M.Wt:
447.6
Formula:
C23H17N3OS3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
397290-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631. PMID: 22634634.

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Keywords: Gue 1654, supplier, Gue1654, OXE-R, modulators, inhibitors, inhibits, selective, beta, gamma, β, γ, signalling, signaling, heterotrimeric, G-proteins, oxeiocosanoid, receptors, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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