Cat. No. 4741
Biological ActivityCalcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912. PMID: 22900474.
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.
Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181. PMID: 22053183.
Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353. PMID: 18162548.
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Citations are publications that use Tocris products. Selected citations for Gadolinium chloride include:
Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. J Immunol 7. PMID: 25873305.
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Keywords: Gadolinium chloride, supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, calcium, channels, blockers, TRP, TRPML, Tocris Bioscience, Other Calcium Channel Blocker products