Cat. No. 4739
Biological ActivityPotassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sharma et al (2012) Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits. Neurol.Res. 34 291. PMID: 22450340.
Zhong et al (2007) Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium. Int.J.Dev.Neurosci. 25 359. PMID: 17804190.
Wallick et al (1997) Effects of ionic channel antagonists barium, cesium, and UL-FS-49 on vagal slowing of atrial rate in dogs. Am.J.Physiol. 273 H2155. PMID: 9374748.
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Keywords: Cesium chloride, supplier, Caesium, chloride, potassium, channel, blockers, If, Ih, currents, neuroprotective, apoptosis, CsCl, Tocris Bioscience, Non-selective / Other Potassium Channel Blocker products
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