LY 333531 hydrochloride

Cat. No. 4738

LY 333531 hydrochloride C28H28N4O3.HCl [169939-93-9]

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Alternative Name: Ruboxistaurin

Chemical Name: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride

Biological Activity

Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

Technical Data

M.Wt:
505.01
Formula:
C28H28N4O3.HCl
Solubility:
Soluble to 20 mM in DMSO
Storage:
Store at -20°C
CAS No:
169939-93-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Faul et al (2003) Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ. Bioorg.Med.Chem.Lett. 13 1857. PMID: 12749884.

Samokhin et al (1999) Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. Eur.J.Pharmacol. 386 297. PMID: 10618482.

Jirousek et al (1996) (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase Cβ. J.Med.Chem. 39 2664. PMID: 8709095.

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Citations are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:

Muellner et al (2015) Targeting a cell state common to triple-negative breast cancers. ASN Neuro 11 789. PMID: 25699542.

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Keywords: LY 333531 hydrochloride, supplier, LY333531, hydrochloride, Ruboxistaurin, protein, kinase, c, PKC, PKCb, isozymes, selective, PKCBI, PKCbetaI, PKCβI, PKCBII, PKCbetaII, PKCβII, PKCB1, PKCbeta1, PKCβ1, PKCB2, PKCbeta2, PKCβ2, inhbitors, inhibits, Tocris Bioscience, Protein Kinase C Inhibitor products

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