AZ 12080282 dihydrochloride

Cat. No. 4838

AZ 12080282 dihydrochloride C23H20N4O2.2HCl

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Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride

Biological Activity

Inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Yang et al (2012) Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg.Med.Chem.Lett. 22 4907. PMID: 22704236.

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Keywords: AZ 12080282 dihydrochloride, supplier, AZ12080282, dihydrochloride, hedgehog, signaling, signalling, inhibitors, inhibits, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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