Cat. No. 4736
Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroa
Biological ActivityInhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111. PMID: 20705791.
Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957. PMID: 21209416.
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Keywords: WIN 18446, supplier, WIN18446, spermatogenesis, inhibitors, inhibits, aldehyde, dehydrogenases, ALDH1a2, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products