Quetiapine hemifumarate

Cat. No. 4735

Quetiapine hemifumarate C21H25N3O2S.0.5C4H4O4 [111974-72-2]

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Alternative Name: ICI 204,636

Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate

Biological Activity

Atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.

Technical Data

Soluble to 50 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine. Neuropsychopharmacology 15 406. PMID: 8887995.

Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285. PMID: 7871032.

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Keywords: Quetiapine hemifumarate, supplier, antipsychotics, serotonin, 5-HT, 5-HT2, dopamine, D2, receptors, ICI204636, antagonists, Tocris Bioscience, Non-selective 5-HT2 Antagonist products

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