Cat. No. 4735
Alternative Name: ICI 204,636
Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-
Biological ActivityAtypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine. Neuropsychopharmacology 15 406. PMID: 8887995.
Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285. PMID: 7871032.
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Keywords: Quetiapine hemifumarate, supplier, antipsychotics, serotonin, 5-HT, 5-HT2, dopamine, D2, receptors, ICI204636, antagonists, Tocris Bioscience, Non-selective 5-HT2 Antagonist products
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April 10 - 13, 2017