Cat. No. 4735
Alternative Name: ICI 204,636
Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-
Biological ActivityAtypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine. Neuropsychopharmacology 15 406. PMID: 8887995.
Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285. PMID: 7871032.
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Keywords: Quetiapine hemifumarate, supplier, antipsychotics, serotonin, 5-HT, 5-HT2, dopamine, D2, receptors, ICI204636, antagonists, Tocris Bioscience, Non-selective 5-HT2 Antagonist products