TRC 051384

Cat. No. 4734

TRC 051384 C25H31N5O4 [867164-40-7]

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Chemical Name: N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea

Biological Activity

Inducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mohanan et al (2011) Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 60 991. PMID: 21167846.

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Keywords: TRC 051384, supplier, TRC051384, potent, inducers, heat, shock, proteins, HSP70, strokes, neuronal, injury, transient, ischemic, stroke, anti-inflammatory, chaperone, Tocris Bioscience, Hsp70 products

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