Cat. No. 4732
Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline
Biological ActivityBlocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program. PMID: 22049577.
Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436. PMID: 21795696.
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Keywords: ML 204, supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, Tocris Bioscience, TRPC Blocker products