Cat. No. 4731
Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-d
Biological ActivityPromotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Minami et al (2012) A small molecule that promotes cardiac differentiation of humam pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448. PMID: 23103164.
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Keywords: KY 02111, supplier, KY02111, stem, cell, differentiation, cardiomyocytes, human, iPSCs, ESCs, Wnt, signaling, pathway, inhibits, inhibitors, Tocris Bioscience, Stem Cell Differentiation products
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