α-Spinasterol

Cat. No. 4729

a-Spinasterol C29H48O [481-18-5]

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Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol

Biological Activity

TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

Technical Data

M.Wt:
412.69
Formula:
C29H48O
Solubility:
Soluble to 10 mM in ethanol with gentle warming
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
481-18-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258. PMID: 22837009.

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Keywords: a-Spinasterol, supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable, Tocris Bioscience, TRPV Antagonist products

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Peripheral Sensitization

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