Cat. No. 4729
Chemical Name: (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
Biological ActivityTRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258. PMID: 22837009.
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Keywords: a-Spinasterol, supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable, Tocris Bioscience, TRPV Antagonist products
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