CTA 056

Cat. No. 4726

CTA 056  [1265822-30-7]

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Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one

Biological Activity

Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Technical Data

M.Wt:
554.68
Formula:
C35H34N6O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1265822-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938. PMID: 22899868.

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ITK

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Keywords: CTA 056, supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, Tocris Bioscience, ITK Inhibitor products

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