BTT 3033

Cat. No. 4724

BTT 3033 C23H20FN5O3S [1259028-99-3]

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Chemical Name: 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide

Biological Activity

Selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. Inhibits platelet aggregation to collagen I coated capillaries under flow. Also inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions.

Technical Data

M.Wt:
465.5
Formula:
C23H20FN5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1259028-99-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Nissinen et al (2012) Novel a21 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694. PMID: 23132859.

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Keywords: BTT 3033, supplier, BTT3033, selective, inhibitors, inhibits, integrins, receptors, alpha2beta1, α2β1, a2b1, collagen, 1, cell, adhesion, Tocris Bioscience, Integrin Receptor Inhibitor products

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