Cat. No. 4723
Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5
Biological ActivityProliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.
Licensing InformationSold under license from St. Jude Childrens Research Hospital
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289. PMID: 22383522.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses T2AA from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: T2AA, supplier, Proliferating, cell, nuclear, antigen, PCNA, inhibitors, inhibits, DNA, replication, forks, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
Find multiple products by catalog number
December 13 - 15, 2016