Cat. No. 4718
Biological ActivitySelective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
(Modifications: Disulfide bridge: 2-17,9-24,16-31)
(Modifications: Ile-35 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Xiao et al (2011) Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV. J.Biol.Chem. 286 27301. PMID: 21659528.
Xiao et al (2008) Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration. J.Biol.Chem. 283 27300. PMID: 18628201.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Huwentoxin IV from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Huwentoxin IV, supplier, Huwentoxin, 4, sodium, channels, NaV1.7, blockers, antagonists, toxins, voltage, gated, Na+, channels, selective, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Potent and selective Nav1.7 channel blockerOD1
Potent hNav1.4, rNav1.6 and rNav1.7 channel activatorMambalgin 1
Selective ASIC1a inhibitor; analgesic
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.