Cat. No. 4715
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piper
Biological ActivityDual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369. PMID: 22860205.
Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407. PMID: 22860210.
Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270. PMID: 19918051.
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Keywords: JZL 195, supplier, JZL195, FAAH, fatty, acid, amide, hydrolase, monoacylglycerol, lipase, MAGL, inhibitors, inhibits, dual, Tocris Bioscience, Fatty Acid Amide Hydrolase Inhibitor products
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