Cat. No. 4715
Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piper
Biological ActivityDual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo. Shown to impair short-term memory in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wise et al (2012) Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. ACS Chem.Neurosci. 3 369. PMID: 22860205.
Wiskerke et al (2012) Characterization of the effects of reuptake and hydrolysis inhibiton on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem.Neurosci. 3 407. PMID: 22860210.
Long et al (2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc.Natl.Acad.Sci.USA 106 20270. PMID: 19918051.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JZL 195 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JZL 195, supplier, JZL195, FAAH, fatty, acid, amide, hydrolase, monoacylglycerol, lipase, MAGL, inhibitors, inhibits, dual, Tocris Bioscience, FAAH Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeableJZP 361
Potent and selective reversible MAGL inhibitorURB 602
Non-competitive MAGL inhibitor(S)-Crizotinib
Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrantJZP 430
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands