Cat. No. 4713
Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3
Biological ActivityMaintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Miyabayashi et al (2007) Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc.Natl.Acad.Sci.U S A 104 5668. PMID: 17372190.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for IQ 1 include:
Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Neurosci 7 10354. PMID: 26838601.
Do you know of a great paper that uses IQ 1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: IQ 1, supplier, IQ1, embryonic, stem, cells, ESCs, pluripotency, dedifferentiation, maintains, cultured, Wnt3a, blocks, differentiation, PP2A, Nkd, Oct4, Sox2, Tocris Bioscience, Stem Cell Proliferation products
Find multiple products by catalog number
New Products in this Area
Induces reprogramming of fibroblasts into functional cardiomyocytesO4I2
Oct3/4 inducer; induces expression of pluripotent-associated genes
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.