IQ 1

Cat. No. 4713

IQ 1 C21H22N4O2 [331001-62-8]

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Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

Biological Activity

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

Technical Data

M.Wt:
362.42
Formula:
C21H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
331001-62-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Miyabayashi et al (2007) Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc.Natl.Acad.Sci.U S A 104 5668. PMID: 17372190.

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Citations are publications that use Tocris products. Selected citations for IQ 1 include:

Long et al (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. J Neurosci 7 10354. PMID: 26838601.

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Keywords: IQ 1, supplier, IQ1, embryonic, stem, cells, ESCs, pluripotency, dedifferentiation, maintains, cultured, Wnt3a, blocks, differentiation, PP2A, Nkd, Oct4, Sox2, Tocris Bioscience, Stem Cell Proliferation products

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