Salmeterol xinafoate

Cat. No. 4712

Salmeterol xinafoate C25H37NO4.C11H8O3 [94749-08-3]

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Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthalenecarboxylic acid salt

Biological Activity

Long-acting β2 adrenergic receptor agonist. Inhibits the release of histamine, leukotrienes and prostaglandin D2, and blocks GM-CSF production from human cultured mast cells. Exhibits efficacious bronchodilatory activity in patients with asthma or chronic obstructive pulmonary disease (COPD).

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Akabane et al (2006) Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. Allergol.Int. 55 387. PMID: 17130681.

Rennard et al (2001) Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease. Am.J.Respir.Crit.Care Med. 163 1087. PMID: 11316640.

Roberts et al (1999) The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur.Respir.J. 14 275. PMID: 10515401.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Salmeterol xinafoate include:

Israël-Assayag et al (2015) ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas. Nat Commun 10 e0120095. PMID: 25799096.

Sykes and Charlton (2012) Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists. Br J Pharmacol 165 2672. PMID: 21883146.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Scola et al (2009) The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol 158 267. PMID: 19371332.

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Keywords: Salmeterol xinafoate, supplier, long, acting, beta2, b2, β2, adrenergics, adrenoceptors, agonists, LABAs, asthma, COPD, respiratory, disease, bronchodilators, Tocris Bioscience, Adrenergic β2 Receptor Agonist products

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