LY 288513

Cat. No. 1524

LY 288513 C22H18BrN3O2 [147523-65-7]

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Chemical Name: (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide

Biological Activity

Selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M.Wt:
436.3
Formula:
C22H18BrN3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
147523-65-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Helton et al (1996) Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol.Biochem.Behav. 53 493. PMID: 8866946.

Rasmussen (1994) CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. Ann.N.Y.Acad.Sci. 713 300. PMID: 8185172.

Rasmussen et al (1992) Electrophysiological effects of diphenylpyrazolidinone cholecystokinin-B and cholecystokinin-A antagonists on midbrain dopamine neurons. J.Pharmacol.Exp.Ther. 264 480.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LY 288513 include:

Wen et al (2012) Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. Front Endocrinol (Lausanne) 13 63. PMID: 22682150.

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Keywords: LY 288513, supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, LY288513, Tocris Bioscience, CCK2 Receptor Antagonist products

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