Hexa-D-arginine

Cat. No. 4711

Hexa-D-arginine D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2

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Biological Activity

Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data

M.Wt:
954.16
Formula:
C36H75N25O6
Sequence:
RRRRRR

(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6=D-Arg)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
673202-67-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. 28 56. PMID: 22886699.

Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275 36741. PMID: 10958789.

If you know of a relevant reference for Hexa-D-arginine please let us know.

Citations are publications that use Tocris products.

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Keywords: Hexa-D-arginine, supplier, Hexa-D-arginine, selective, furin, inhibitors, inhibits, paired, basic, amino, acid, cleaving, enzyme, PACE, subtilisin-like, proprotein, convertases, Tocris Bioscience, Other Protease Inhibitor products

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