Cat. No. 4705

Chetomin C31H30N6O6S4 [1403-36-7]

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Chemical Name: (3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Biological Activity

Targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro.

Technical Data

Soluble in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lee and Mapp (2010) Transcriptional switches: chemical approaches to gene regulation. J.Biol.Chem. 285 11033. PMID: 20147748.

Staab et al (2007) Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. BMC Cancer 13 213. PMID: 17999771.

Kung et al (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33. PMID: 15261140.

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Keywords: Chetomin, supplier, NSC289491, p300/CBP, disrupts, interaction, HIF1a, HIF2a, STAT2, hypoxia, inducible, factors, hypoxic, gene, expression, Tocris Bioscience, Hypoxia Inducible Factor products

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