Cat. No. 4700
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-p
Biological ActivityNegative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241. PMID: 22589534.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PU 02 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PU 02, supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Tocris Bioscience, 5-HT3 Receptor Modulator products
Find multiple products by catalog number
December 13 - 15, 2016