Cat. No. 4700
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-p
Biological ActivityNegative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241. PMID: 22589534.
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Keywords: PU 02, supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Tocris Bioscience, 5-HT3 Receptor Modulator products
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