PU 02

Cat. No. 4700

PU 02 C16H12N4S [313984-77-9]

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Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine

Biological Activity

Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).

Technical Data

Soluble to 100 mM in DMSO
>97 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241. PMID: 22589534.

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Keywords: PU 02, supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Tocris Bioscience, 5-HT3 Receptor Modulator products

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5-HT Scientific Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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