A 331440 dihydrochloride

Cat. No. 4697

A 331440 dihydrochloride  [1049740-32-0]

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Chemical Name: 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride

Biological Activity

High affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

Technical Data

Soluble to 100 mM in water and to 20 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183. PMID: 15033391.

Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144. PMID: 15447739.

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Keywords: A 331440 dihydrochloride, supplier, A331440, dihydrochloride, high, affinity, selective, histamine, histaminergic, H3, receptor, antagonists, anti-obesity, obese, Tocris Bioscience, Histamine H3 Receptor Antagonist products

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