Cat. No. 4691
Chemical Name: 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-
Biological ActivitySelective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866. PMID: 22770500.
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Keywords: NAV 26, supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products