Cat. No. 4691
Chemical Name: 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-
Biological ActivitySelective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866. PMID: 22770500.
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Keywords: NAV 26, supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products