Cat. No. 4691
Chemical Name: 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-
Biological ActivitySelective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866. PMID: 22770500.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NAV 26 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NAV 26, supplier, NAV26, selective, NAv1.7, ion, channels, blockers, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Potent and selective Nav1.7 channel blockerOD1
Potent hNav1.4, rNav1.6 and rNav1.7 channel activatorMambalgin 1
Selective ASIC1a inhibitor; analgesic
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.