Cat. No. 4688
Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetra
Biological ActivityInactive control of GSK J1 (Cat No.4593) (IC50 > 100 μM for inhibition of JMJD3/UTX). Cell permeable ester derivative, GSK J5 (Cat. No. 4689), also available.
Licensing InformationThis compound is supplied in conjunction with the Structural Genomics Consortium. For further details of GSK J2, an inactive isomer of GSK J1, please visit the GSK J1 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kruidenier et al (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488 404. PMID: 22842901.
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Keywords: GSK J2, supplier, GSKJ2, histone, demethylases, inhibitors, inhibits, UTX, JMJD3, KDM6, H3K27, epigenetics, Tocris Bioscience, Histone Demethylase Inhibitor products