Cat. No. 4686
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(
Biological ActivityValosin-containing protein (VCP) inhibitor. Binds to the N domain of VCP, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892. PMID: 22360440.
Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51. PMID: 19132064.
Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683. PMID: 9366096.
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Citations are publications that use Tocris products. Selected citations for Xanthohumol include:
den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324. PMID: 27819292.
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Keywords: Xanthohumol, supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, Tocris Bioscience, Other ATPase Inhibitor products