Cat. No. 4686

Xanthohumol C21H22O5 [6754-58-1]

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Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Biological Activity

Valosin-containing protein (VCP) inhibitor. Binds to the N domain of VCP, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sasazawa et al (2012) Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 7 892. PMID: 22360440.

Inokoshi et al (2009) Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 62 51. PMID: 19132064.

Tabata et al (1997) Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46 683. PMID: 9366096.

If you know of a relevant reference for Xanthohumol please let us know.

Citations are publications that use Tocris products. Selected citations for Xanthohumol include:

den Brok et al (2016) Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation Nature Communications 7 13324. PMID: 27819292.

Do you know of a great paper that uses Xanthohumol from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Xanthohumol, supplier, valosin-containing, protein, VCP, transitional, endoplasmic, reticulum, ATPase, TER, inhibitors, autophagosome, autophagy, apoptosis, inhibits, Tocris Bioscience, Other ATPase Inhibitor products

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NMS 873

Potent and selective valosine containing protein (VCP; p97) allosteric inhibitor

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