Cat. No. 4685
Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypr
Biological ActivityCryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094. PMID: 22798407.
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Keywords: KL 001, supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Tocris Bioscience, Other Transcription Factor products