Cat. No. 4685
Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypr
Biological ActivityCryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094. PMID: 22798407.
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Keywords: KL 001, supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Tocris Bioscience, Other Transcription Factor products