KL 001

Cat. No. 4685

KL 001 C21H22N2O4S [309928-48-1]

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Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide

Biological Activity

Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Technical Data

M.Wt:
398.48
Formula:
C21H22N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
309928-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094. PMID: 22798407.

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Keywords: KL 001, supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Tocris Bioscience, Other Transcription Factor products

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