Cat. No. 4684
Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioi
Biological ActivityHistone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639. PMID: 22724510.
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Keywords: Daminozide, supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Tocris Bioscience, Histone Demethylase Inhibitor products
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KDM4A inhibitor; also NF-κB activator
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