Daminozide

Cat. No. 4684

Daminozide C6H12N2O3 [1596-84-5]

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Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid

Biological Activity

Histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).

Technical Data

M.Wt:
160.17
Formula:
C6H12N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Storage:
Store at RT
CAS No:
1596-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639. PMID: 22724510.

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Keywords: Daminozide, supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Tocris Bioscience, Histone Demethylase Inhibitor products

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