RFRP 3 (human)

Cat. No. 4683

RFRP 3 (human) Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2

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Alternative Name: Neuropeptide NPVF

Biological Activity

Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.

Technical Data

M.Wt:
969.15
Formula:
C45H72N14O10
Sequence:
VPNLPQRF

(Phe-8 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
311309-27-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rizwan et al (2012) RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology 153 3770. PMID: 22691552.

Ubuka et al (2009) Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4 e8400. PMID: 20027225.

Hinuma et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat.Cell Biol. 2 703. PMID: 11025660.

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Keywords: RFRP 3 (human), supplier, RFamide-related, peptide, RFRP3, neuropeptide, FF/AF, agonists, gonadotropin-inhibitory, gonadotrophin-inhibitory, hormone, homologs, orthologs, GnIH, Neuropeptide, NPVF, Tocris Bioscience, Neuropeptide FF/AF Receptor Agonist products

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