CYM 50358 hydrochloride

Cat. No. 4679

CYM 50358 hydrochloride C20H18Cl2N2O2.HCl

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Chemical Name: N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride

Biological Activity

Potent S1P4 antagonist (IC50 = 25 nM). Displays selectivity for S1P4 against S1P1, S1P2, S1P3 and S1P5 receptors.

Technical Data

M.Wt:
425.74
Formula:
C20H18Cl2N2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cencetti et al (2013) TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 27 4532. PMID: 23913862.

Guerrero et al (2011) Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg.Med.Chem.Lett. 21 3632. PMID: 21570287.

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Keywords: CYM 50358 hydrochloride, supplier, CYM50358, hydrochloride, sphingosine-1-phosphate, receptors, S1P, S1P4, antagonists, potent, selective, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products

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