CYM 50308

Cat. No. 4678

CYM 50308 C20H21F2N3O2S [1345858-76-5]

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Chemical Name: (2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone

Biological Activity

Potent and selective sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 values are 56 nM and 2100 nM for S1P4 and S1P5 receptors, respectively). Displays no activity at S1P1, S1P2 and S1P3 receptors at concentrations up to 25 μM.

Technical Data

M.Wt:
405.46
Formula:
C20H21F2N3O2S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1345858-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Urbano et al (2011) Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 21 6739. PMID: 21982495.

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Keywords: CYM 50308, supplier, CYM50308, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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