CYM 50260

Cat. No. 4677

CYM 50260 C14H11Cl3FNO2 [1355026-60-6]

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Chemical Name: 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine

Biological Activity

Potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

Technical Data

M.Wt:
350.6
Formula:
C14H11Cl3FNO2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1355026-60-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Guerrero et al (2011) Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg.Med.Chem.Lett. 22 537. PMID: 22119461.

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Keywords: CYM 50260, supplier, CYM50260, sphingosine-1-phosphate, receptors, S1P4, agonists, potent, selective, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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