CCT 031374 hydrobromide
Cat. No. 4675
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydr
Biological ActivityInhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
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Certificate of Analysis / Safety Data Sheet
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963. PMID: 20610623.
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Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572. PMID: 26496941.
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