CCT 031374 hydrobromide
Cat. No. 4675
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydr
Biological ActivityInhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963. PMID: 20610623.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572. PMID: 26496941.
Do you know of a great paper that uses CCT 031374 hydrobromide from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CCT 031374 hydrobromide, supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Tocris Bioscience, β-catenin products
Find multiple products by catalog number
New Products in this Area
Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) proteinAMBMP hydrochloride
Wnt canonical signaling activator; also tubulin polymerization inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.