CCT 031374 hydrobromide
Cat. No. 4675
Chemical Name: 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydr
Biological ActivityInhibitor of TCF-dependent transcription. Blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ewan et al (2010) A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70 5963. PMID: 20610623.
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Citations are publications that use Tocris products. Selected citations for CCT 031374 hydrobromide include:
Liu et al (2015) β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Nature 36 1572. PMID: 26496941.
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Keywords: CCT 031374 hydrobromide, supplier, CCT031374, hydrobromide, TCF, transcription, inhibitors, inhibits, beta-catenin, b-catenin, β-catenin, stabilization, Tocris Bioscience, β-catenin products
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