Cat. No. 4674
Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[
Biological ActivitySelective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576. PMID: 22544264.
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Keywords: CZC 24832, supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, Tocris Bioscience, PI 3-kinase Inhibitor products
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