CZC 24832

Cat. No. 4674

CZC 24832 C15H17FN6O2S [1159824-67-5]

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Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide

Biological Activity

Selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Bergamini et al (2012) A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat.Chem.Biol. 8 576. PMID: 22544264.

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Keywords: CZC 24832, supplier, CZC24832, PI3K, PI3-K, PI3kinase, phosphoinositide, 3-kinase, kinases, gamma, inhibitors, inhibits, inflammation, Tocris Bioscience, PI 3-kinase Inhibitor products

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