Cat. No. 4673
Chemical Name: [5-(2-Fluorophenyl)-2-methyl-4-thia
Biological ActivityPotent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM). Exhibits 100-fold selectivity for OX1 over OX2 receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca2+ mobilization in CHO-DG44 cells stably transfected with the OX1 receptor.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ellis et al (2006) Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Biol.Chem. 281 38812. PMID: 17015451.
Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340. PMID: 14691055.
If you know of a relevant reference for SB 674042 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SB 674042 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SB 674042, supplier, Potent, selective, non, peptide, OX1, receptors, antagonists, orexin1, orexin-1, SB674042, Tocris Bioscience, OX1 Receptor Antagonist products
Find multiple products by catalog number
September 27 - 30, 2017