SB 611812

Cat. No. 4670

SB 611812 C17H16Cl3F3N2O3S [345892-71-9]

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Chemical Name: 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide

Biological Activity

Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
491.74
Formula:
C17H16Cl3F3N2O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
345892-71-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Papadopoulos et al (2008) Urotensin-II and cardiovascular remodeling. Peptides 29 764. PMID: 17988761.

Bousette et al (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 27 2919. PMID: 16919371.

Bousette et al (2006) Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation. J.Mol.Cell Cardiol. 41 285. PMID: 16797584.

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Keywords: SB 611812, supplier, SB611812, GSK, urotensin-II, urotensin, receptors, antagonists, cardiac, dysfunction, remodeling, remodelling, Tocris Bioscience, Urotensin-II Receptor Antagonist products

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