Cat. No. 4669
Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazo
Biological ActivityNeuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79. PMID: 15582717.
Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47. PMID: 12047910.
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Citations are publications that use Tocris products.
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Keywords: GW 438014A, supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, Tocris Bioscience, NPY Receptor Antagonist products
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