GW 438014A

Cat. No. 4669

GW 438014A  [469861-49-2]

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Chemical Name: N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate

Biological Activity

Neuropeptide (NPY) Y5 receptor antagonist (IC50 = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
437.51
Formula:
C22H19N3O.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
469861-49-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Benmaamar et al (2005) Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79. PMID: 15582717.

Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul.Pept. 106 47. PMID: 12047910.

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Keywords: GW 438014A, supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, Tocris Bioscience, NPY Receptor Antagonist products

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