GW 627368

Cat. No. 4668

GW 627368  [439288-66-1]

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Chemical Name: 4-(4-,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide

Biological Activity

Selective prostanoid EP4 receptor competitive antagonist with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platelet aggregation.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
544.62
Formula:
C30H28N2O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
439288-66-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wilson et al (2006) GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br.J.Pharmacol. 148 326. PMID: 16604093.

Jones and Chan et al (2005) Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences. Prostaglandins Leukot.Essent.Fatty.Acids. 72 289. PMID: 15763441.

If you know of a relevant reference for GW 627368 please let us know.

Citations are publications that use Tocris products. Selected citations for GW 627368 include:

Edén et al (2015) Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets. Diabetologia 58 2563. PMID: 26271343.

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Keywords: GW 627368, supplier, GW627368, Prostanoid, receptors, EP4, TP, competitive, antagonists, platelet, aggregation, Tocris Bioscience, Prostanoid Receptor Antagonist products

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