UNC 1215

Cat. No. 4666

UNC 1215 C32H43N5O2

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Chemical Name: 2-Phenylamino-1,4-[4-(pyrrolidinyl)piperidinyl)benzamide

Biological Activity

Potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1215 is reviewed on the chemical probes website.

Technical Data

M.Wt:
529.72
Formula:
C32H43N5O2
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in 2eq.HCl
Purity:
>99 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

James et al (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat.Chem.Biol. [Epub ahead of print]. PMID: 23292653.

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Keywords: UNC 1215, supplier, UNC1215, MBT, L3MBTL3, domain, epigenetics, readers, inhibitors, inhibits, selective, potent, in, vitro, sgc, Tocris Bioscience, MBT Domain Inhibitor products

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