Cat. No. 4666
Chemical Name: 2-Phenylamino-1,4-[4-(pyrrolidinyl)
Biological ActivityPotent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM). Displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Disrupts subnuclear localization and foci formation of fluorescently-labeled L3MBTL3 in HEK293 cells.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1215 probe summary on the SGC website.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1215 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
James et al (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat.Chem.Biol. [Epub ahead of print]. PMID: 23292653.
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Citations are publications that use Tocris products.
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Keywords: UNC 1215, supplier, UNC1215, MBT, L3MBTL3, domain, epigenetics, readers, inhibitors, inhibits, selective, potent, in, vitro, sgc, Tocris Bioscience, MBT Domain Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.