Cat. No. 4662
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-pi
Biological ActivityInhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040. PMID: 22554036.
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Keywords: SMANT hydrochloride, supplier, Smoothened, Smo, hedgehog, Hh, signaling, signalling, inhibitors, inhibits, SMANT, Tocris Bioscience, Smoothened Receptor products
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