SMANT hydrochloride

Cat. No. 4662

SMANT hydrochloride C16H23BrN2O.HCl [1177600-74-6]

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Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride

Biological Activity

Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M.Wt:
375.73
Formula:
C16H23BrN2O.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1177600-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040. PMID: 22554036.

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Keywords: SMANT hydrochloride, supplier, Smoothened, Smo, hedgehog, Hh, signaling, signalling, inhibitors, inhibits, SMANT, Tocris Bioscience, Smoothened Receptor products

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