Cat. No. 4659
Alternative Name: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Biological ActivityAntineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944. PMID: 21613406.
Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788. PMID: 18979208.
Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130. PMID: 6220000.
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Keywords: Floxuridine, supplier, FdUrd, antiproliferatives, antineoplastic, antimetabolites, thymidylate, synthetases, synthases, inhibititors, DNA, synthesis, antimetabolites, chemotherapeutics, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products
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