Cat. No. 4659
Alternative Name: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Biological ActivityAntineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944. PMID: 21613406.
Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788. PMID: 18979208.
Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130. PMID: 6220000.
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Keywords: Floxuridine, supplier, FdUrd, antiproliferatives, antineoplastic, antimetabolites, thymidylate, synthetases, synthases, inhibititors, DNA, synthesis, antimetabolites, chemotherapeutics, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products
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