Floxuridine

Cat. No. 4659

Floxuridine C9H11FN2O5 [50-91-9]

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Alternative Name: FdUrd

Chemical Name: 5-Fluoro-2'-deoxyuridine

Biological Activity

Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Technical Data

M.Wt:
246.19
Formula:
C9H11FN2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
50-91-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944. PMID: 21613406.

Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788. PMID: 18979208.

Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130. PMID: 6220000.

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Keywords: Floxuridine, supplier, FdUrd, antiproliferatives, antineoplastic, antimetabolites, thymidylate, synthetases, synthases, inhibititors, DNA, synthesis, antimetabolites, chemotherapeutics, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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