Hypericin

Cat. No. 1520

Hypericin C30H16O8 [548-04-9]

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Chemical Name: 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Technical Data

M.Wt:
504.45
Formula:
C30H16O8
Solubility:
Soluble to 10 mM in ethanol with gentle warming and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
548-04-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Agostinis et al (2002) Hypericin in cancer treatment: more light on the way. Int.J.Biochem.Cell Biol. 34 221. PMID: 11849990.

Hwang et al (2001) Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 21 2649. PMID: 11724334.

Lenard et al (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc.Natl.Acad.Sci.U.S.A. 90 158. PMID: 7678335.

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Citations are publications that use Tocris products.

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Keywords: Hypericin, supplier, inhibitors, inhibits, tyrosine, kinases, Protein, Kinase, Broad, Spectrum, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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