Cat. No. 4655
Alternative Name: S3I-201
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)s
Biological ActivitySelectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lin et al (2009) The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28 961. PMID: 19137011.
Siddiquee et al (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 104 7391. PMID: 17463090.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses NSC 74859 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: NSC 74859, supplier, NSC74859, STAT3, inhibitors, inhibits, DNA-binding, apoptosis, Tocris Bioscience, STAT Inhibitor products
Find multiple products by catalog number
New Products in this Area
Inhibitor of Keap1- Nrf2 interactionRA 839
Nrf2 activator; inhibits Nrf2/Keap1 interactionGN 44028
Potent HIF-1α inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.