ML 171

Cat. No. 4653

ML 171 C14H11NOS [6631-94-3]

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Chemical Name: 2-Acetylphenothiazine

Biological Activity

NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Drummond et al (2011) Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat.Rev.Drug Discov. 10 453. PMID: 21629295.

Gianni et al (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem.Biol. 5 981. PMID: 20715845.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ML 171 include:

Cheung et al (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Anal Bioanal Chem 30 52. PMID: 26679840.

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Keywords: ML 171, supplier, ML171, NADPH, oxidases, 1, NOX1, reactive, oxygen, species, ROS, inhibits, inhibitors, selective, cell, permeable, Tocris Bioscience, NADPH Oxidase Inhibitor products

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