Cat. No. 4653
Chemical Name: 2-Acetylphenothiazine
Biological ActivityNADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Drummond et al (2011) Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat.Rev.Drug Discov. 10 453. PMID: 21629295.
Gianni et al (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem.Biol. 5 981. PMID: 20715845.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ML 171 include:
Cheung et al (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Anal Bioanal Chem 30 52. PMID: 26679840.
Do you know of a great paper that uses ML 171 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 171, supplier, ML171, NADPH, oxidases, 1, NOX1, reactive, oxygen, species, ROS, inhibits, inhibitors, selective, cell, permeable, Tocris Bioscience, NADPH Oxidase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective myeloperoxidase (MPO) inhibitorINCB 024360-analog
Potent indoleamine 2,3-dioxygenase (IDO) inhibitorLM 10
Selective tryptophan 2,3-dioxygenase (TDO) inhibitorNoxA1ds
Potent and selective NADPH oxidase 1 (NOX1) inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.