Cat. No. 4652

SAHA C14H20N2O3 [149647-78-9]

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Alternative Name: Vorinostat

Chemical Name: N-Hydroxy-N'-phenyloctanediamide

Biological Activity

Inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Huangfu et al (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat.Biotechnol. 26 795. PMID: 18568017.

Marks and Breslow (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat.Biotechnol. 25 84. PMID: 17211407.

Leoni et al (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc.Natl.Acad.Sci.U.S.A 99 2995. PMID: 11867742.

Butler et al (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 60 5165. PMID: 11016644.

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Keywords: SAHA, supplier, histone, deacetylases, HDACs, inhibits, inhibitors, Class, I, Class, II, vorinostat, anticancer, antiproliferatives, epigenetics, proapoptotic, Tocris Bioscience, Histone Deacetylase Inhibitor products

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