Cat. No. 4652
Alternative Name: Vorinostat
Chemical Name: N-Hydroxy-N'-phenyloctanediamide
Biological ActivityInhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Huangfu et al (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat.Biotechnol. 26 795. PMID: 18568017.
Marks and Breslow (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat.Biotechnol. 25 84. PMID: 17211407.
Leoni et al (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc.Natl.Acad.Sci.U.S.A 99 2995. PMID: 11867742.
Butler et al (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 60 5165. PMID: 11016644.
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Keywords: SAHA, supplier, histone, deacetylases, HDACs, inhibits, inhibitors, Class, I, Class, II, vorinostat, anticancer, antiproliferatives, epigenetics, proapoptotic, Tocris Bioscience, Histone Deacetylase Inhibitor products
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